Let me preface this by saying that I'm not a reloader, but I have studied it intensely and watched like a hawk people who are excellent at doing it. But consistency will always equal accuracy.

As far as runout, I have a buddy of mine who hunts worldwide and allowed a fellow to load big game rounds for him. He went to Montana and it took 6 rounds to kill an elk 500 yards out. This guy doesn't miss. The guide almost kicked his ass all the way down the mountain and my buddy was pissed and humiliated. There was runout in the loads and it led to the round gouging the lead rifling just outside the throat and ruining the barrel on the $5000 rifle, just from firing a handful of shots.